wisp-science: Open-source, local-first desktop AI research workbench for scientific computing with Python/R, MCP

by xuzhougeng · MCP Server · ★ 998

Last updated: · Indexed by AgentSkillsHub · Auto-synced every 8h

Security audit verdict: SAFE · quality 68/100

None of the 42 rules matched — no credential harvesting, no data exfiltration, no curl-pipe-shell installer. Scanned against 42 published rules built on the SlowMist agent-security taxonomy, refreshed every 8 hours. Full audit →

The quality score combines nine heuristic checks of the repo and its README: completeness, clarity, specificity, examples, structure, agent readiness, step-by-step content, instruction quality and security notes. It rates how well the project explains itself to an agent, not the code.

agent-skillsai-agentai-assistantai-for-scienceai4sciencebioinformaticscomputational-biologydesktop-appllmlocal-first

Quick Facts

Stars998
Forks103
LanguageRust
CategoryMCP Server
LicenseAGPL-3.0
Quality Score68/100
Open Issues3
Last Updated2026-10-02
Created2026-07-01
Platformsmcp, rust
Est. Tokens~27k

About wisp-science

Wisp Science — Local-first AI research workbench English | 简体中文 Wisp Science is an open-source, local-first desktop AI research assistant and scientific computing workbench. It connects to OpenAI-compatible and Anthropic models, runs persistent Python and R environments on local, SSH, WSL, and GPU compute, loads reusable Agent Skills (), and reaches 80 bioinformatics and computational biology...

Compatible Skills

These tools work well together with wisp-science for enhanced workflows:

  • k-dense-byok — semantic(0.52)+shared_fw(anthropic,openai)+rare_topics+similar_pop+shared_platform (73%)
  • SciAgent-Skills — semantic(0.37)+complementary+shared_fw(anthropic)+rare_topics+similar_pop (69%)
  • DrugClaw — semantic(0.31)+complementary+shared_fw(anthropic,openai)+rare_topics+similar_pop (66%)
  • open-science — semantic(0.38)+shared_fw(anthropic,openai)+rare_topics+similar_pop+shared_platform (63%)
  • AlterLab-Academic-Skills — semantic(0.40)+shared_fw(anthropic)+rare_topics+similar_pop+shared_platform (60%)

wisp-science alternative? Top 6 similar tools

Looking for a wisp-science alternative? If you're comparing wisp-science with other mcp server tools, these 6 projects are the closest alternatives on Agent Skills Hub — ranked by topic overlap, star count, and community traction.

  • open-science by ai4s-research · ⭐ 2.1k

    Open Science Desktop — local-first, model-agnostic AI research workbench for macOS, Windows & Linux. Open-sour

  • k-dense-byok by K-Dense-AI · ⭐ 1.4k

    An AI co-scientist running on your desktop. Claude Science but better.

  • clawpanel by qingchencloud · ⭐ 2.9k

    🦞 OpenClaw & Hermes Agent 多引擎 AI 管理面板 — 内置 AI 助手（工具调用 + 图片识别 + 多模态），一键安装 | Tauri v2 跨平台桌面应用 | 11 种语言

  • awesome-bio-agent-skills by BioTender-max · ⭐ 204

    A curated collection of AI agent skills for biomedical research, covering genomics, proteomics, single-cell an

  • skills-hub by qufei1993 · ⭐ 1.8k

    A cross-platform desktop app to manage Agent Skills in one place and sync them to multiple AI coding tools’ gl

  • comfyui-mcp by artokun · ⭐ 890

    Local-first, agent-native control plane for ComfyUI — MCP server + sidebar agent that generates images, video

More MCP Server Tools

Explore other popular mcp server tools:

View all MCP Server tools →

Popular Rust Agent Tools

How this security grade is produced

Grades come from a rule-based scan built on the SlowMist agent-security taxonomy: 42 published rules, covering credential harvesting, data exfiltration, curl | sh installers and more. It is a first-layer scan, not a manual audit — we say so rather than overstate it.

The scale of the problem is documented independently: Liu et al. (2026), in a study of 31,132 agent skills, report that 26.1% contain security vulnerabilities. Our own full-catalog census is published as a citable open dataset.

Sources & who's responsible:

View on GitHub → Browse MCP Server tools